Can you imagine a treatment that not only improves the appearance of your skin but also repairs and regenerates it from within? That is the promise of polynucleotides — one of the most revolutionary innovations in regenerative aesthetic medicine. At Clínica de Medicina Estética Mandíbula de Diamante, with locations in...
The New Ally in Regenerative Facial Rejuvenation
Imagine a treatment that not only improves the appearance of your skin but also repairs and regenerates it from within. That’s the promise of polynucleotides, one of the most revolutionary innovations in regenerative aesthetic medicine. At Aesthetic Medicine Clinic Mandíbula de Diamante, with centers in Barcelona and Madrid, we apply this advanced technique to help our patients achieve visibly younger, firmer, and more radiant skin—without invasive methods.
What Are Polynucleotides?
Polynucleotides are natural DNA fragments (typically derived from salmon DNA), biocompatible and completely safe for aesthetic use. Their ability to regenerate tissue and stimulate natural cellular repair processes makes them a powerful tool for facial rejuvenation.
When applied to the skin, polynucleotides act as biostimulators, boosting collagen production, enhancing deep hydration, and repairing visible signs of skin aging.
What Are Polynucleotides Used For in Facial Aesthetics?
Polynucleotides are used to improve skin quality, elasticity, and density. Their benefits include:
- Stimulating collagen and elastin production, essential for firm and supple skin
- Deep hydration, by retaining moisture in the tissues
- Cellular repair, helping regenerate tired or damaged skin
- Brightening the complexion, giving a healthy "glow" effect
- Softening fine lines and expression wrinkles, especially around the eyes and forehead
Where Can This Treatment Be Applied?
The polynucleotide treatment is very versatile and can be used on:
- Full face
- Eye contour (dark circles, fine lines)
- Neck and décolleté
- Hands
- Even on younger skin to prevent early signs of aging
It is suitable for all skin types, including sensitive or reactive skin.
How Many Sessions Are Needed and What Is the Procedure Like?
Usually, 2 to 4 sessions are recommended, spaced about 2–3 weeks apart, depending on the patient’s skin condition and goals.
The procedure is quick and nearly painless (topical anesthesia can be used if needed), and there is no downtime. Mild redness may appear immediately after the session but fades within a few hours.
How Is It Different From Other Treatments Like Hyaluronic Acid or Mesotherapy?
- Hyaluronic acid hydrates and fills, but does not regenerate
- Mesotherapy delivers vitamins, but does not directly stimulate collagen production
- Polynucleotides, on the other hand, activate natural tissue regeneration, repair damaged skin, and stimulate your own collagen and elastin production
This makes them a unique, deep-acting treatment that also complements other aesthetic procedures.
Why choose Clínica Mandíbula de Diamante?
At Mandíbula de Diamante, we offer this treatment with:
- Experienced medical professionals, trained in regenerative and biostimulatory aesthetics
- High-quality, certified products, safe and effective
- Personalized facial diagnosis and treatment plans
- Clinics in Barcelona and Madrid, with warm, ethical, and confidential care
Our approach is not just aesthetic—we aim to restore your skin’s health and vitality from within.
Give Your Skin Its Natural Vitality Back
If you're looking for a safe, modern, and highly effective way to rejuvenate your face—without surgery or artificial fillers—polynucleotides may be the perfect choice for you.
Book your personalized consultation today at our Barcelona or Madrid clinics, and discover how the regenerative power of science can transform your skin.




